The research aims at identifying the links between the geographical patterns of knowledge creation, and the innovation and economic performances of entrepreneurial ecosystems. For this purpose, we map the knowledge creation characteristics of different entrepreneurial ecosystems in Europe across different industries, identify key actors (universities, start-ups, incumbent firms, financial intermediaries), and analyse their behaviour. We also detect potential sources of synergies between these actors, the boundary conditions relating to actors’ specific characteristics under which these synergies materialize, and measure their …